Intermittent fasting, beoordeeld op basis van de gerandomiseerde onderzoeken

Vasten werkt voor gewichtsverlies. De interessante vraag is waarom — en de beste onderzoeken suggereren dat het antwoord minder spannend is dan het publieke debat.

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The one-paragraph summary

Intermittent fasting produces weight loss. In head-to-head trials against ordinary calorie restriction, it produces roughly the same weight loss. That makes fasting a useful way to eat less rather than a metabolic trick — which is good news if you find it easier than counting, and irrelevant if you do not.

Circadian

Does when you eat matter?

This is where fasting research is genuinely interesting. Late eating measurably changes energy expenditure.

Mechanism

The autophagy claims

Real biology, wildly overstated in humans. What has actually been measured, and at what fasting length.

Performance

Training fasted

Performance effects are small and depend heavily on what you are asking your body to do.

Safety

Who should not fast

Pregnancy, type 1 diabetes, insulin-treated type 2, eating disorder history, and several medications.

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Diets, drugs, behaviour and maintenance — ranked by the strength of the evidence behind them.

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